KMID : 0370920140310010052
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Yeungnam Univercity Journal of Medicine 2014 Volume.31 No. 1 p.52 ~ p.55
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Hereditary protein S deficiency presenting acute pulmonary embolism
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Kim Ji-Wan
Kim Sung-Hea Jung Sang-Man Park Soo-Youn Yu Hyung-Min An Sang-Hee Kang Seong-Hui Kim Hyun-Joong
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Abstract
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Protein S deficiency is one of the several risk factors for thrombophilia and can cause blood clotting disorders such as deep vein thrombosis and pulmonary embolism. A 54-year-old man was admitted with the complaint of dyspnea and was diagnosed with pulmonary embolism. The patient had very low level of free protein S, total protein S antigen, and protein S activity (type I protein S deficiency). In history taking, we found that his mother, 78 year old, had a history of same disease 10 years ago, and confirmed the pronounced low level of protein S. The patient¡¯s son also had very low level of protein S, however there had not been any history of pulmonary embolism yet. This case study suggests that asymptomatic persons with a family history of protein S deficiency and pulmonary embolism should be checked regularly for early detection of the disease, as protein S deficiency can be suspected.
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KEYWORD
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Pulmonary embolism, Protein S deficiency, Family history
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